Glitch-free discretely programmable clock generation on chip

In this paper we describe a solution for a glitch-free discretely programmable clock generation unit (DPGC). The scheme is compatible with a GALS communication scheme in the sense that clock gating and clock pausing are possible. Besides, the proposed scheme does not require waiting for a new clock as the frequency change is seen as almost instantaneously. A prototype has been designed for a 0.13µm triple-well CMOS process technology to also study the properties of the scheme with respect to voltage scaling

Technology exploration for adaptive power and frequency scaling in 90nm CMOS

In this paper we examine the expectations and limitations of design technologies such as adaptive voltage scaling (AVS) and adaptive body biasing (ABB) in a modern deep sub-micron process. To serve this purpose, a set of ring oscillators was fabricated in a 90nm triple-well CMOS technology. The analysis hereby presented is based on two ring oscillators running at 822MHz and 93MHz, respectively. Measurement results indicate that it is possible to reach 13.8x power savings by 3.4x frequency downscaling using AVS, ±11% power and ±8% frequency tuning at nominal conditions using ABB only, 22x power savings with 5x frequency downscaling by combining AVS and ABB, as well as 22x leakage reduction

Atypical hemolytic uremic syndrome: Unique clinical presentation linked to rare CFHR5 mutation.

In adults, the diagnosis and the clinical management of atypical hemolytic uremic syndrome is still a challenge for hematologists [1–3]. Here, we report a case of a 40-year-old previously healthy man presented to the emergency department with fever (39.6◦C) and bilateral persistent foot pain

Mesoglycan connects Syndecan-4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis in vitro.

Mesoglycan is a mixture of glycosaminoglycans (GAG) with fibrinolytic effects and the potential to enhance skin wound repair. Here, we have used endothelial cells isolated from Wild Type (WT) and Syndecan-4 null (Sdc4-/-) C57BL/6 mice to demonstrate that mesoglycan promotes cell motility and in vitro angiogenesis acting on the co-receptor Syndecan-4 (SDC4). This latter is known to participate in the formation and release of extracellular vesicles (EVs). We characterized EVs released by HUVECs and assessed their effect on angiogenesis. Particularly, we focused on Annexin A1 (ANXA1) containing EVs, since they may contribute to tube formation via interactions with Formyl peptide receptors (FPRs). In our model, the bond ANXA1-FPRs stimulates the release of vascular endothelial growth factor (VEGF-A) that interacts with vascular endothelial receptor-2 (VEGFR2) and activates the pathway enhancing cell motility in an autocrine manner, as shown by Wound-Healing/invasion assays, and the induction of Endothelial to Mesenchymal Transition (EndMT). Thus, we have shown for the first time that mesoglycan exerts its pro-angiogenic effects in the healing process triggering the activation of the three interconnected molecular axis: mesoglycan-SDC4, EVs-ANXA1-FPRs and VEGF-A-VEGFR2

Mass Media, gender and crime: wefts and senses about violence against women

[ES] Resumen El artículo presenta los resultados de una investigación colectiva que tuvo como propósito analizar, desde una mirada crítica y de género/feminista, narrativas periodísticas, discursos y sentidos en disputa expresados por medios gráficos de la provincia de Mendoza, Argentina, sobre distintas problemáticas de género como la violencia contra las mujeres. Entre otros hallazgos, a través del análisis cuanti-cualitativo de las construcciones noticiosas, el trabajo revela de qué manera la agenda de los temas de género ha quedado subsumida a la problemática de la violencia de género/femicidios tratada desde el punto de vista policial. La espectacularización a través de diferentes herramientas como la personalización, la descontextualización y la dramatización, se ha convertido en un mecanismo recurrente en la construcción de tales informaciones.[EN] Abstract The article presents the results of a collective research that had the purpose of analyzing, from a critical and gender / feminist perspective, journalistic narratives, discourses and senses in dispute expressed by graphic media of the province of Mendoza, Argentina, on different topics of gender such as violence against women. Among other findings, through the quantitative-qualitative analysis of news constructions, the paper reveals how the agenda of gender topics has been subsumed to the problem of gender violence / femicide treated from the police point of view. The spectacularization, through different tools such as personalization, decontextualization and dramatization, has become a recurrent mechanism in the construction of this information

Recovery of dialysis patients with COVID-19 : health outcomes 3 months after diagnosis in ERACODA

Background. Coronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients 3 months after their COVID-19 diagnosis. Methods. We analyzed data on dialysis patients diagnosed with COVID-19 from 1 February 2020 to 31 March 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes studied were patient survival, residence and functional and mental health status (estimated by their treating physician) 3 months after COVID-19 diagnosis. Complete follow-up data were available for 854 surviving patients. Patient characteristics associated with recovery were analyzed using logistic regression. Results. In 2449 hemodialysis patients (mean ± SD age 67.5 ± 14.4 years, 62% male), survival probabilities at 3 months after COVID-19 diagnosis were 90% for nonhospitalized patients (n = 1087), 73% for patients admitted to the hospital but not to an intensive care unit (ICU) (n = 1165) and 40% for those admitted to an ICU (n = 197). Patient survival hardly decreased between 28 days and 3 months after COVID-19 diagnosis. At 3 months, 87% functioned at their pre-existent functional and 94% at their pre-existent mental level. Only few of the surviving patients were still admitted to the hospital (0.8-6.3%) or a nursing home (∼5%). A higher age and frailty score at presentation and ICU admission were associated with worse functional outcome. Conclusions. Mortality between 28 days and 3 months after COVID-19 diagnosis was low and the majority of patients who survived COVID-19 recovered to their pre-existent functional and mental health level at 3 months after diagnosis

Heterogeneous clustered processors Organization and design

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN038902 / BLDSC - British Library Document Supply CentreGBUnited Kingdo